By Seth Joel Corey, Marek Kimmel, Joshua N. Leonard
The blood method is multi-scale, from the organism to the organs to cells to intracellular signaling pathways to macromolecule interactions. Blood comprises circulating cells, mobile fragments (platelets and microparticles), and plasma macromolecules. Blood cells and their fragments consequence from a highly-ordered technique, hematopoiesis. Definitive hematopoiesis happens within the bone marrow, the place pluripotential stem cells supply upward thrust to a number of lineages of hugely really good cells. Highly-productive and consistently regenerative, hematopoiesis calls for a microenvironment of mesenchymal cells and blood vessels.
A platforms Biology method of Blood is split into 3 major sections: simple parts, physiological techniques, and scientific functions. utilizing blood as a window, you possibly can research overall healthiness and ailment via this specified software field with reactive organic fluids that mirrors the present hemodynamics of the vessel partitions and some of the blood mobilephone kinds. Many blood illnesses, infrequent and customary can and feature been exploited utilizing structures biology methods with profitable effects and as a result excellent versions for structures medication. extra importantly, hematopoiesis bargains the best studied structures with perception into stem mobilephone biology, mobile interplay, improvement; linage programing and reprograming which are each day encouraged via the main mature and understood regulatory networks.
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Extra resources for A Systems Biology Approach to Blood
By taking advantage of the thin bone of the calvarium in mice. Simultaneous visualization of transplanted HSCs, OBs, bone, and vasculature facilitates the in vivo tracking of individual HSCs and analysis of the relative positions of the visualized niche components . This way, information on the migratory behavior of single HSCs becomes accessible and its analysis promises to shed light on the spatiotemporal organization of the stem cell niche. Spatiotemporal Modeling Each of the approaches described above provides information related to different levels of the organization hierarchy in the stem cell niche.
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32 A. Krinner and I. Roeder In this chapter, we tried to summarize (without claiming completeness) important facts about the stem cell niche in the hematopoietic system. In particular, we discussed the possibility to use mathematical models, as one important means of a systems biological approach, to quantitatively study the rules that drive the dynamics of stem cell systems. As shown above, even rather simple models can considerably help to identify regulatory principles, which are consistent with multiple in vitro and in vivo results, and, therefore, to guide further experimental strategies.