By Paul E. Thompson

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The gravity of the situation is aggravated by the fact that these drugs have been the mainstay in malaria chemotherapy because of important limitations of alternative agents. Chlorguanide and pyrimethamine, as mentioned previously, act too slowly for satisfactory effect in the treatment of acute P. 34 2. GEOGRAPHIC DISTRIBUTION AND GENERAL TYPES OF DRUG RESISTANCE falciparum infections. Some strains of P. falciparum, particularly in Southeast Asia, are resistant to all the above drugs and are commonly referred to as multiresistant strains.

2, 271 (1953). 55. W. Trager, Exp. Parasitol. 8, 265 (1959). 56. R. Ferone and G. H. Hitchings, J. Protozool. 13, 504 (1966). 56a. G. H. Hitchings and J. J. Burchall, Advan. Enzymol. 27, (417 (1965). 57. R. F. Ferone, J. J·. Burchall, and G. H. Hitchings, Mol. Pharmacol. 5, 49 (1969). 58. E. G. Platzer, J. Parasitol. 54, 267 (1970). 59. W. E. Gutteridge and P. I. Trigg, / . Parasitol. 56, 132 (1970). 60. R. F. Ferone, Personal Communication (1971). 61. J. J. Trop. Med. Hyg. 15,818 (1966). 62. J.

W. Trager, Exp. Parasitol. 8, 265 (1959). 56. R. Ferone and G. H. Hitchings, J. Protozool. 13, 504 (1966). 56a. G. H. Hitchings and J. J. Burchall, Advan. Enzymol. 27, (417 (1965). 57. R. F. Ferone, J. J·. Burchall, and G. H. Hitchings, Mol. Pharmacol. 5, 49 (1969). 58. E. G. Platzer, J. Parasitol. 54, 267 (1970). 59. W. E. Gutteridge and P. I. Trigg, / . Parasitol. 56, 132 (1970). 60. R. F. Ferone, Personal Communication (1971). 61. J. J. Trop. Med. Hyg. 15,818 (1966). 62. J. Cenedella, Amer. J.

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