By Abelson J.N., Simon M.I., Phillips I.M. (eds.)

Antisense know-how is the power to govern gene expression inside of mammalian cells delivering strong experimental methods for the examine of gene functionality and gene law. for instance, tools that inhibit gene expression enable reviews which probe the traditional functionality of a particular product inside of a mobilephone. Such technique can be utilized in lots of disciplines resembling pharmacology, oncology, genetics, mobile biology, developmental biology, molecular biology, biochemistry, and neurosciences. This quantity should be a very very important software in biomedical-oriented examine. The seriously acclaimed laboratory normal for greater than 40 years, tools in Enzymology is without doubt one of the so much hugely revered guides within the box of biochemistry. given that 1955, each one quantity has been eagerly awaited, often consulted, and praised by way of researchers and reviewers alike. Now with greater than three hundred volumes (all of them nonetheless in print), the sequence includes a lot fabric nonetheless correct this present day - really a necessary ebook for researchers in all fields of existence sciences.

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Extra info for Antisense Technology: General Methods, Methods of Delivery, and RNA Studies Part A

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150j. p. Messina, G. S. Gilkeson, and D. S. Pisetsky, J. Immunol. 147, 1759 (1991). 151 E. Kuramoto, O. Yano, Y. Kimura, M. Baba, T. Makino, S. Yamamoto, T. Yamamoto, T. Kataoka, and T. Tokunaga, Jpn. J. Cancer Res. 83, 1128 (1992). [ 1] PROGRESS IN ANTISENSE TECHNOLOGY 33 lymphoid hyperplasia in the spleen and lymph nodes of rodents caused by repeated administration of these compounds (see later). 152 We also have evidence of enhanced cytokine release by immunocompetent cells when exposed to phosphorothioates in vitro.

41 upper lane, gene accession number J05561) and Shimomura et al. 42 (lower lane, gene accession number D00634)]. The ATG translation initiation codon is highlighted in boldface fonts and inconsistent bases between two reports in italic fonts. The target region of a 15-mer A S - O D N is underlined. specificity, which must be confirmed by checking with GenBank for existing sequences to avoid any significant homology with other mRNAs. Figure 2 shows the BLAST search result of a 15-mer A S O D N designed specifically for the rat/3radrenoceptor, which turns out to be conserved in/31-adrenoceptor m R N A of rat, mouse, human, monkey, and dog, but has no appreciable overlapping with other rat mRNAs.

Clin. Invest. 88, 1190 (1991). 139I. Kitajima, T. Shinohara, J. Bilakovics, D. A. Brown, X. Xiao, and M. Nerenberg, Science 251t, 1792 (1992). 14oK. A. Higgins, J. R. Perez, T. A. Coleman, K. Dorshkind, W. A. McComas, U. M. Sarmiento, C. A. Rosen, and R. Narayan, Proc. Natl. Acad. Sci. A. 9tl, 9901 (1993). 141N, Hijiya, J. Zhang, M. Z. Ratajczak, J. A. Kant, K. DeRiel, M. Herlyn, G. Zon, and A. M. Gewirtz, Proc. Natl. Acad. Sci. A. 91, 4499 (1994). [1] PROGRESSIN ANTISENSETECHNOLOGY 31 in mouse liver without effects on any other isotype.

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