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If they scale, you are looking at periodical noise. References 1. , and Chih-Chung, C. (1991) Reconstruction of STM and AFM images distorted by finite-size tips. Surface Sci. 253, 353–364. 2. , and Van Haesendonck, C. (1991) Can atomic force microscopy tips be inspected by atomic force microscopy? J. Vac. Sci. Technol. B. 9, 1309–1312. 3. Keller, D. and Chou, C. C. (1992) Imaging steep, high structures by scanning force microscopy with electron beam deposited tips. Surface Sci. 268, 333–339. 4.

2 Lamellipodial region of a live human fibroblast in its biocompatible fluid medium on a culture dish substrate. 03 N/m. The lever-imposed force loading was approx 3 nN and the fast-scan speed was 150 µm/s. The contour line reveals submembrane structure. has two distinct advantages. The effect of lateral forces is effectively eliminated (important because cells have low resistance to shear stress). Because the interaction now arises from an impulse action at one extreme of the oscillatory motion of the tip, the inertia of the sample will resist deformation.

2003) A label-free protein assay based on a nanomechanical cantilever array. Nanotechnology 14, 86–90. Micromechanical Biosensors 49 14. , and Boisen A. (2001) Cantilever-based bio-chemical sensor integrated in a microfluidic handling system, in IEEE Int. Conf. Micro. Electro. Mech. , Tech. Dig. Institute of Electrical and Electronic Engineers, New York, 14th, pp. 401–404. 15. Hansen, K. , Ji, H. , Wu, G. , et al. (2001) Cantilever-based optical deflection assay for discrimination of DNA single-nucleotide mismatches.

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