By Phyllis M. Wise (auth.), Francis L. Bellino Ph.D. (eds.)

BiologyofMenopause offers the lawsuits of a global symposium held from September 10-13, 1998 in Newport seashore, CA. The complaints evaluate present wisdom and explores destiny learn instructions at the biologic alterations of the hypothalamic-pituitary-ovarian axis around the menopausal transition and the linked alterations in physiologic platforms open air of the HPO axis, together with the mind, the musculoskeletal and cardiovascular platforms. also, chapters current new equipment of research and rising parts of research.

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Extra resources for Biology of Menopause

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This conclusion is controversial, however, because of the ongoing debate over the relative contributions of hypothalamic versus pituitary mechanisms underlying steroid negative feedback ( 16,39-42). Proopiomelanocortin Gene Expression Is Decreased in the Infundibular Nucleus of Postmenopausal Women Our most recent studies have focused on the POMC system of neurons in the medial basal hypothalamus (43). Considerable evidence suggests that hypothalamic l3-endorphin neurons have an important inhibitory role in the regulation of GnRH secretion in the primate (39,44).

7. Kalra SP. Mandatory neuropeptide-steroid signaling for the preovulatory luteinizing hormone-releasing hormone discharge. Endocrinol Rev 1993;14:507~38. 8. King JC, Rubin BS. GnRH subgroups: a microarchitecture. , eds. Modes of action of GnRH and GnRH analogs. New York: SpringerVerlag, 1992:161~78. 9. Silverman A-J, Witkin JW, Silverman RC, Gibson MJ. Modulation of GnRH neuronal activity as evidenced by uptake of fluorogold from the vasculature. Synapse 1990;6: 154-{)0. 10. Yasin M, Dalkin AC, Haisenleder DJ, Kerrigan JR, Marshall JC.

Matt DW, Sayles TE, Jih MH, Kauma SW, Lu JKH. Alterations in the postovariectomy increases in gonadotropin secretion in middle-aged persistent-estrous rats: correlation with pituitary gonadotropin subunit gene expression. Neuroendocrinology 1993;57:351-58. Lloyd JM, Hoffman GE, Wise PM. Decline in immediate early gene expression in gonadotropin-releasing hormone neurons during proestrus in regularly cycling, middle-aged rats. Endocrinology 1994; 134: 1800--5. Rubin BS, Mitchell S, Lee CE, King Jc.

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