By Eugene C. Toy, William E. Seifert Jr., Henry W. Strobel, Konrad P. Harms

Fifty scientific situations assist you excel in biochemistry classes and the USMLE Step 1

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Additional resources for Case Files: Biochemistry, 2nd Edition

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The aminoacyl tRNA binds the triplet codon at the A site. The formyl-methionyl group forms a peptide bond with the amino group of the aminoacyl tRNA in the P site, releasing the now uncharged tRNAfMet, which exits the ribosome assembly through the E site. (3) Elongation continues until the ribosome encounters one of the stop codons UAA, UAG, and UGA. (4) Termination of protein synthesis occurs with the help of release factors which cleave the peptide chain from the tRNA and dissolve the ribosomal complex.

2. 3. 4. Know the structure of deoxyribonucleic acid (DNA) and RNA. Understand the processes of denaturation, renaturation, and hybridization of DNA. Know the differences between RNA and DNA. Be familiar with the differences between human and viral/bacterial DNA and RNA. Definitions Base pairing: The hydrogen bonds formed between complementary bases that are part of the polynucleotide chains of nucleic acids. The base pairing is specific in that adenine will base pair with thymine (uracil in RNA) and guanine will pair with cytosine.

This is a process that takes place on ribosomes and requires the participation of aminoacylcharged tRNAs, mRNA, and various initiation and elongation factors. Exons: Sequence of nucleotides that appear in mature RNA. Introns: Sequences of nucleotides that do not appear in mature RNA but are excised and do not appear in messenger RNA. Spliceosome: A complex of small nuclear ribonucleoprotein particles (snRNPs) that catalyze the splicing, or removal of introns, of mRNA precursors. DISCUSSION DNA is the biological blueprint material, which authentically carries all the necessary cellular information and passes it from generation to generation.

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