By P. Illes, H. Zimmermann
The examine of purinergic mechanisms has for lengthy been all for the activities of the nucleoside adenosine, wherein the contribution of nucleotides to the signaling platforms has been underestimated. in accordance with the court cases of a IUPHAR satellite tv for pc convention held in Leipzig, Germany, this ebook bargains a entire replace and review of nucleotide unencumber, the constitution and serve as of nucleotide receptors, nucleotide-metabolizing ecto-enzymes in addition to the physiological features of nucleotides within the anxious procedure. The body structure and molecular biology of receptors for ATP and different nucleotides are tested, as are the body structure and molecular biology of enzymes that hydrolyze extracellular nucleotides. at this time, a pharmacology of the nucleotide signaling approach is being constructed. Of specific curiosity is the construction of receptor subtype-specific antagonists and of substances that selectively impact the extracellular life of the nucleotide. a great resource of reference for institutes of pharmacology, biochemistry, neurology, zoology, and body structure, and for the pharmaceutical undefined.